Clinically significant interaction between metronidazole and Warfarin has been reported.
Metronidazole has been found to increase prothrombin time. It is preferable to discontinue oral anticoagulants 24 hours prior to administration of Metrogyl I.V.
Simultaneous administration of metronidazole and disulfiram has been reported to cause acute psychosis and confusional state.
It is advisable to avoid mixing I.V. infusions of different drugs. In keeping with this rule; Metrogyl INJECTIONS should not be mixed with any other drug.